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Three new myrsinol diterpenes from Euphorbia prolifera and their neuroprotective activities.

ABSTRACT: Three new myrsinol diterpenes were isolated from the roots of Euphorbia prolifera. Their structures were elucidated as 2?-O-isobutyryl-3?,5?,7?,10,15?-penta-O-acetyl-14?-O-benzoyl-10,18-dihydromyrsinol (1), 2?-O-isobutyryl-3?-O-propion-yl-5?,7?,10,15?-tetra-O-acetyl-10,18-dihydromyrsinol (2), and 2?,14?-di-O-benzoyl-3?,5?,7?,10,15?-penta-O-acetyl-10,18-dihydromyrsinol (3) on the basis of spectroscopic data analyses (IR, ESI-MS, HR-ESI-MS, and 1D and 2D NMR). Their neuroprotective activities were evaluated and compounds 1 and 2 showed neuroprotective effects against MPP+ -induced neuronal cell death in SH-SY5Y cells.

SUBMITTER: Xu J

PROVIDER: S-EPMC6268895 | biostudies-other | 2012

REPOSITORIES: biostudies-other

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Three new myrsinol diterpenes from Euphorbia prolifera and their neuroprotective activities.

Xu Jing J Jin Daqing D Guo Ping P Xie Chunfeng C Fang Lingzhi L Guo Yuanqiang Y

Molecules (Basel, Switzerland) 20120809 8

Three new myrsinol diterpenes were isolated from the roots of Euphorbia prolifera. Their structures were elucidated as 2α-O-isobutyryl-3β,5α,7β,10,15β-penta-O-acetyl-14α-O-benzoyl-10,18-dihydromyrsinol (1), 2α-O-isobutyryl-3β-O-propion-yl-5α,7β,10,15β-tetra-O-acetyl-10,18-dihydromyrsinol (2), and 2α,14α-di-O-benzoyl-3β,5α,7β,10,15β-penta-O-acetyl-10,18-dihydromyrsinol (3) on the basis of spectroscopic data analyses (IR, ESI-MS, HR-ESI-MS, and 1D and 2D NMR). Their neuroprotective activities were ...[more]

PMID: 22878226

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