Synthesis and protective effect of new ligustrazine-benzoic acid derivatives against CoCl2-induced neurotoxicity in differentiated PC12 cells.
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ABSTRACT:
SUBMITTER: Wang P
PROVIDER: S-EPMC6270565 | biostudies-other | 2013
REPOSITORIES: biostudies-other
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Synthesis and protective effect of new ligustrazine-benzoic acid derivatives against CoCl2-induced neurotoxicity in differentiated PC12 cells.
Wang Penglong P Zhang Honggui H Chu Fuhao F Xu Xin X Lin Jinxuan J Chen Chunxiao C Li Guoliang G Cheng Yatao Y Wang Lin L Li Qiang Q Zhang Yuzhong Y Lei Haimin H
Molecules (Basel, Switzerland) 20131018 10
A series of novel ligustrazine-benzoic acid derivatives were synthesized and evaluated for their protective effect against cobalt chloride-induced neurotoxicity in differentiated PC12 cells. Combining hematoxylin and eosin staining, we found compound that (3,5,6-trimethylpyrazin-2-yl)methyl 3-methoxy-4-[(3,5,6-trimethylpyrazin-2-yl)methoxy]benzoate (4a) displayed promising protective effect on the proliferation of the injured PC12 cells (EC50 = 4.249 µM). Structure-activity relationships are bri ...[more]
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