Ontology highlight
ABSTRACT:
SUBMITTER: Fu H
PROVIDER: S-EPMC6271340 | biostudies-other | 2014 Oct
REPOSITORIES: biostudies-other
Fu Haoran H Zhang Yuhang Y Wang Xiqing X Han Yingzhi Y Peng Xiao X Efferth Thomas T Efferth Thomas T Fu Yujie Y
Molecules (Basel, Switzerland) 20141031 11
A series of new aminomethylated derivatives of isoliquiritigenin was synthesized. The structures of the compounds were confirmed by IR, MS, NMR, 13C-NMR and elemental analyses. Cytotoxic activities of these derivatives towards the human prostatic cell line PC-3, human mammary cancer cell line MCF-7 and human oophoroma cell line HO-8910 in vitro were tested. The IC50 values showed cytotoxic activities of some of these new derivatives were relatively strong. Furthermore, tumor growth inhibition in ...[more]