Ontology highlight
ABSTRACT:
SUBMITTER: Mu S
PROVIDER: S-EPMC6271649 | biostudies-other | 2014
REPOSITORIES: biostudies-other
Mu Shuai S Liu Ying Y Gong Min M Liu Deng-Ke DK Liu Chang-Xiao CX
Molecules (Basel, Switzerland) 20140224 2
Twenty-one non-peptide substituted desloratadine class compounds were synthesized as novel arginine vasopressin receptor antagonists from desloratadine via successive acylation, reduction and acylation reactions. Their structures were characterized by 1H-NMR and HRMS, their biological activity was evaluated by in vitro and in vivo studies. The in vitro binding assay and cAMP accumulation assay indicated that these compounds are potent selective V2 receptor antagonists. Among them compounds 1n, 1 ...[more]