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Cyclin-dependent kinase inhibitors as marketed anticancer drugs: where are we now? A short survey.

ABSTRACT: In the early 2000s, the anticancer drug imatinib (Glivec®) appeared on the market, exhibiting a new mode of action by selective kinase inhibition. Consequently, kinases became a validated therapeutic target, paving the way for further developments. Although these kinases have been thoroughly studied, none of the compounds commercialized since then target cyclin-dependent kinases (CDKs). Following a recent and detailed review on the subject by Galons et al., we concentrate our attention on an updated list of compounds under clinical evaluation (phase I/II/III) and discuss their mode of action as ATP-competitive inhibitors. CDK inhibition profiles and clinical development stages are reported for the 14 compounds under clinical evaluation. Also, tentative progress for forthcoming potential ATP non-competitive inhibitors and allosteric inhibitors are briefly described, along with their limitations.

SUBMITTER: Mariaule G

PROVIDER: S-EPMC6271685 | biostudies-other | 2014 Sep

REPOSITORIES: biostudies-other

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Cyclin-dependent kinase inhibitors as marketed anticancer drugs: where are we now? A short survey.

Mariaule Gaëlle G Belmont Philippe P

Molecules (Basel, Switzerland) 20140911 9

In the early 2000s, the anticancer drug imatinib (Glivec®) appeared on the market, exhibiting a new mode of action by selective kinase inhibition. Consequently, kinases became a validated therapeutic target, paving the way for further developments. Although these kinases have been thoroughly studied, none of the compounds commercialized since then target cyclin-dependent kinases (CDKs). Following a recent and detailed review on the subject by Galons et al., we concentrate our attention on an upd ...[more]

PMID: 25215591

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