Ontology highlight
ABSTRACT:
SUBMITTER: Oledzka E
PROVIDER: S-EPMC6271874 | biostudies-other | 2014
REPOSITORIES: biostudies-other
Oledzka Ewa E Sobczak Marcin M Nalecz-Jawecki Grzegorz G Skrzypczak Agata A Kolodziejski Waclaw W
Molecules (Basel, Switzerland) 20140606 6
The development and characterization of novel macromolecular conjugates of ampicillin using branched biodegradable polymers has been described in this study. The conjugates have been prepared coupling the β-lactam antibiotic with branched polymer matrices based on the natural oligopeptide core. The cyto- and genotoxicity of the synthesized polymers were evaluated with a bacterial luminescence test, two protozoan assays and Salmonella typhimurium TA1535. The presence of a newly formed covalent bo ...[more]