Ontology highlight
ABSTRACT:
SUBMITTER: Li D
PROVIDER: S-EPMC6272893 | biostudies-other | 2016 Sep
REPOSITORIES: biostudies-other
Li Dahong D Hu Xu X Han Tong T Liao Jie J Xiao Wei W Xu Shengtao S Li Zhanlin Z Wang Zhenzhong Z Hua Huiming H Xu Jinyi J
Molecules (Basel, Switzerland) 20160908 9
A series of nine enmein-type ent-kaurane diterpenoid and furoxan-based nitric oxide (NO) donor hybrids (10a-i) were designed and synthesized from commercially available oridonin (1). These hybrids were evaluated for their antiproliferative activity against Bel-7402, K562, MGC-803, and CaEs-17 human cancer cell lines and L-02 normal liver cells. The antiproliferative activity against tumor cells was stronger than the lead compound 1 and parent molecule 9 in most cases. Especially, compound 10f sh ...[more]