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Mexicanolide-Type Limonoids from the Roots of Trichilia sinensis.


ABSTRACT: Four new mexicanolide-type limonoids 1-4, along with two known limonoids 5-6, were isolated from the ethanolic extracts of roots of the Traditional Chinese Medicine Trichilia sinensis. Their structures were unambiguously determined by analysis of spectroscopic data, including 1D and 2D NMR as well as MS, and by comparison with literature data. In addition, the acetylcholinesterase (AChE) inhibitory activity of compounds 1-6 was evaluated by the Ellman method. All these compounds showed weak AChE inhibitory activity, with the inhibition percentages ranging from 18.5% to 27.8%.

SUBMITTER: Liu SB 

PROVIDER: S-EPMC6273291 | biostudies-other | 2016 Aug

REPOSITORIES: biostudies-other

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Mexicanolide-Type Limonoids from the Roots of Trichilia sinensis.

Liu Shou-Bai SB   Mei Wen-Li WL   Chen Hui-Qin HQ   Guo Zhi-Kai ZK   Dai Hao-Fu HF   Wang Zhu-Nian ZN  

Molecules (Basel, Switzerland) 20160830 9


Four new mexicanolide-type limonoids 1-4, along with two known limonoids 5-6, were isolated from the ethanolic extracts of roots of the Traditional Chinese Medicine Trichilia sinensis. Their structures were unambiguously determined by analysis of spectroscopic data, including 1D and 2D NMR as well as MS, and by comparison with literature data. In addition, the acetylcholinesterase (AChE) inhibitory activity of compounds 1-6 was evaluated by the Ellman method. All these compounds showed weak AChE  ...[more]

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