Ontology highlight
ABSTRACT:
SUBMITTER: Martella E
PROVIDER: S-EPMC6274803 | biostudies-other | 2018 Nov
REPOSITORIES: biostudies-other
Martella Elisa E Ferroni Claudia C Guerrini Andrea A Ballestri Marco M Columbaro Marta M Santi Spartaco S Sotgiu Giovanna G Serra Massimo M Donati Davide Maria DM Lucarelli Enrico E Varchi Greta G Duchi Serena S Duchi Serena S
International journal of molecular sciences 20181120 11
Osteosarcoma therapy might be moving toward nanotechnology-based drug delivery systems to reduce the cytotoxicity of antineoplastic drugs and improve their pharmacokinetics. In this paper, we present, for the first time, an extensive chemical and in vitro characterization of dual-loaded photo- and chemo-active keratin nanoparticles as a novel drug delivery system to treat osteosarcoma. The nanoparticles are prepared from high molecular weight and hydrosoluble keratin, suitably functionalized wit ...[more]