Ontology highlight
ABSTRACT:
SUBMITTER: Anselm E
PROVIDER: S-EPMC6277087 | biostudies-other | 2018 Nov
REPOSITORIES: biostudies-other
Anselm Eduard E Thomae Andreas W AW Jeyaprakash A Arockia AA Heun Patrick P
Nucleic acids research 20181101 21
The evolutionarily conserved nucleoplasmin family of histone chaperones has two paralogues in Drosophila, named Nucleoplasmin-Like Protein (NLP) and Nucleophosmin (NPH). NLP localizes to the centromere, yet molecular underpinnings of this localization are unknown. Moreover, similar to homologues in other organisms, NLP forms a pentamer in vitro, but the biological significance of its oligomerization has not been explored. Here, we characterize the oligomers formed by NLP and NPH in vivo and find ...[more]