Ontology highlight
ABSTRACT:
SUBMITTER: Zhao Z
PROVIDER: S-EPMC6294380 | biostudies-other | 2018
REPOSITORIES: biostudies-other
Zhao Zhenze Z Partridge Veronica V Sousares Michaela M Shelton Spencer D SD Holland Cory L CL Pertsemlidis Alexander A Du Liqin L
PloS one 20181214 12
microRNA-2110 (miR-2110) was previously identified as inducing neurite outgrowth in a neuroblastoma cell lines BE(2)-C, suggesting its differentiation-inducing and oncosuppressive function in neuroblastoma. In this study, we demonstrated that synthetic miR-2110 mimic had a generic effect on reducing cell survival in neuroblastoma cell lines with distinct genetic backgrounds, although the induction of cell differentiation traits varied between cell lines. In investigating the mechanisms underlyin ...[more]