Ontology highlight
ABSTRACT:
SUBMITTER: Montoir D
PROVIDER: S-EPMC6295873 | biostudies-other | 2018 Dec
REPOSITORIES: biostudies-other
Chemical science 20180920 46
We describe herein a Pd-catalyzed methodology for the thioglycoconjugation of iodoaryl peptides and aminoacids. This operationally simple process occurs under semi-aqueous conditions and displays wide substrate scope. The strategy has been successfully applied to both the thioglycosylation of unprotected peptides and the generation of thioglyco-aminoacid building blocks, including those suitable for solid phase peptide synthesis. To demonstrate the broad potential of this technique for late stag ...[more]