Ontology highlight
ABSTRACT:
SUBMITTER: Ron-Harel N
PROVIDER: S-EPMC6310842 | biostudies-other | 2018 Dec
REPOSITORIES: biostudies-other
Ron-Harel Noga N Notarangelo Giulia G Ghergurovich Jonathan M JM Paulo Joao A JA Sage Peter T PT Santos Daniel D Satterstrom F Kyle FK Gygi Steven P SP Rabinowitz Joshua D JD Sharpe Arlene H AH Haigis Marcia C MC
Proceedings of the National Academy of Sciences of the United States of America 20181210 52
T cell-mediated immune responses are compromised in aged individuals, leading to increased morbidity and reduced response to vaccination. While cellular metabolism tightly regulates T cell activation and function, metabolic reprogramming in aged T cells has not been thoroughly studied. Here, we report a systematic analysis of metabolism during young versus aged naïve T cell activation. We observed a decrease in the number and activation of naïve T cells isolated from aged mice. While young T cel ...[more]