Ontology highlight
ABSTRACT:
SUBMITTER: Li L
PROVIDER: S-EPMC6310889 | biostudies-other | 2018 Dec
REPOSITORIES: biostudies-other
Li Linwei L Mao Aihua A Wang Peng P Ning Guozhu G Cao Yu Y Wang Qiang Q
Biology open 20181217 12
Pharyngeal pouches, a series of outpocketings derived from the foregut endoderm, are essential for craniofacial skeleton formation. However, the molecular mechanisms underlying endodermal pouch-regulated head cartilage development are not fully understood. In this study, we find that zebrafish <i>dmrt2b</i>, a gene encoding Doublesex- and Mab-3-related transcription factor, is specifically expressed in endodermal pouches and required for normal pharyngeal cartilage development. Loss of <i>dmrt2b ...[more]