Prevalence of ROS1 fusion in Chinese patients with non-small cell lung cancer.

ABSTRACT: BACKGROUND:The study was conducted to investigate the clinicopathological features and prevalence of ROS1 gene fusion in Chinese patients with non-small cell lung cancer (NSCLC). METHODS:The presence of ROS1 fusion was assessed by quantitative real-time PCR. Associations between ROS1 fusion and clinical characteristics were analyzed. RESULTS:In total, 6066 patients with pathologically confirmed NSCLC and ROS1 fusion test results were enrolled. The average age was 60.89?±?10.60?years and fusion was detected in 157 (2.59%) patients. Fusion frequency was significantly correlated with age, gender, smoking status (all P??0.05). Age, smoking status, and lymph node stage were statistically significantly correlated with ROS1 fusion frequency (all P?

SUBMITTER: Zhang Q 

PROVIDER: S-EPMC6312842 | biostudies-other | 2019 Jan

REPOSITORIES: biostudies-other