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Anti-GAD Antibody-associated Syndrome Presenting with Limb Myoclonus.

ABSTRACT: Background:The clinical spectrum of anti-glutamic acid decarboxylase (GAD) antibody-associated neurologic syndromes is expanding, with focal, generalized, and atypical forms. Case Report:We describe a 59-year-old female showing continuous right lower limb myoclonus and mild encephalopathy. These symptoms started 2 weeks prior to evaluation. The patient had great improvement with intravenous steroids. An autoantibody panel was positive for anti-GAD. Discussion:Various clinical manifestations, including myoclonus, may relate to anti-GAD antibodies. The treatment options available include symptomatic drugs, intravenous immunoglobulin, steroids, and other immunosuppressant agents.

SUBMITTER: Manzke P

PROVIDER: S-EPMC6315060 | biostudies-other | 2018

REPOSITORIES: biostudies-other

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Anti-GAD Antibody-associated Syndrome Presenting with Limb Myoclonus.

Manzke Pedro P Grippe Talyta T Tavares Georgia L GL Leal Lucas C LC Roze Emmanuel E Apartis Emmanuelle E Maciel Dias Ronaldo R Ferreira André G F AGF

Tremor and other hyperkinetic movements (New York, N.Y.) 20181101

<h4>Background</h4>The clinical spectrum of anti-glutamic acid decarboxylase (GAD) antibody-associated neurologic syndromes is expanding, with focal, generalized, and atypical forms.<h4>Case report</h4>We describe a 59-year-old female showing continuous right lower limb myoclonus and mild encephalopathy. These symptoms started 2 weeks prior to evaluation. The patient had great improvement with intravenous steroids. An autoantibody panel was positive for anti-GAD.<h4>Discussion</h4>Various clinic ...[more]

PMID: 30622836

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