Ontology highlight
ABSTRACT:
SUBMITTER: Holstein E
PROVIDER: S-EPMC6321118 | biostudies-other | 2018 Dec
REPOSITORIES: biostudies-other
Holstein Elisa E Binder Mathias M Mikulits Wolfgang W
International journal of molecular sciences 20181218 12
Signaling of the receptor tyrosine kinase Axl and its ligand Gas6 is crucially involved in the development of liver fibrosis and hepatocellular carcinoma (HCC) by activation of hepatic stellate cells and modulation of hepatocyte differentiation. Shedding of Axl's ectodomain leads to the release of soluble Axl (sAxl), which is increased in advanced fibrosis and in early-to-late stage HCC in the presence and absence of cirrhosis. Here, we focus on the dynamics of Axl receptor shedding and delineat ...[more]