Ontology highlight
ABSTRACT:
SUBMITTER: McLaren JE
PROVIDER: S-EPMC6341181 | biostudies-other | 2019 Feb
REPOSITORIES: biostudies-other
McLaren James E JE Clement Mathew M Marsden Morgan M Miners Kelly L KL Llewellyn-Lacey Sian S Grant Emma J EJ Rubina Anzelika A Gimeno Brias Silvia S Gostick Emma E Stacey Maria A MA Orr Selinda J SJ Stanton Richard J RJ Ladell Kristin K Price David A DA Humphreys Ian R IR
Journal of immunology (Baltimore, Md. : 1950) 20190201 3
Candidate vaccines designed to generate T cell-based immunity are typically vectored by nonpersistent viruses, which largely fail to elicit durable effector memory T cell responses. This limitation can be overcome using recombinant strains of CMV. Proof-of-principle studies have demonstrated the potential benefits of this approach, most notably in the SIV model, but safety concerns require the development of nonreplicating alternatives with comparable immunogenicity. In this study, we show that ...[more]