Ontology highlight
ABSTRACT:
SUBMITTER: Revell C
PROVIDER: S-EPMC6364585 | biostudies-other | 2019 Jan
REPOSITORIES: biostudies-other
Proceedings. Biological sciences 20190101 1895
Many biological processes, including tissue morphogenesis, are driven by cell sorting. However, the primary mechanical drivers of sorting in multicellular aggregates (MCAs) remain controversial, in part because there is no appropriate computational model to probe mechanical interactions between cells. To address this important issue, we developed a three-dimensional, local force-based simulation based on the subcellular element method. In our method, cells are modelled as collections of locally ...[more]