Ontology highlight
ABSTRACT:
SUBMITTER: Ravindra M
PROVIDER: S-EPMC6382392 | biostudies-other | 2018 Mar
REPOSITORIES: biostudies-other
Ravindra Manasa M Wallace-Povirk Adrianne A Karim Mohammad A MA Wilson Mike R MR O'Connor Carrie C White Kathryn K Kushner Juiwanna J Polin Lisa L George Christina C Hou Zhanjun Z Matherly Larry H LH Gangjee Aleem A
Journal of medicinal chemistry 20180221 5
Tumor-targeted specificities of 6-substituted pyrrolo[2,3- d]pyrimidine analogues of 1, where the phenyl side-chain is replaced by 3',6' (5, 8), 2',5' (6, 9), and 2',6' (7, 10) pyridyls, were analyzed. Proliferation inhibition of isogenic Chinese hamster ovary (CHO) cells expressing folate receptors (FRs) α and β were in rank order, 6 > 9 > 5 > 7 > 8, with 10 showing no activity, and 6 > 9 > 5 > 8, with 10 and 7 being inactive, respectively. Antiproliferative effects toward FRα- and FRβ-expressi ...[more]