Spontaneous Selective Preconcentration Leveraged by Ion Exchange and Imbibition through Nanoporous Medium.

ABSTRACT: Manipulating mechanism of particle's motion has been extensively studied for the sample preparation in microfluidic applications including diagnostics, food industries, biological analyses and environmental monitoring. However, most of conventional methods need additional external forces such as electric field or pressure and complicated channel designs, which demand highly complex fabrication processes and operation strategies. In addition, these methods have inherent limitations of dilution or mixing during separation or preconcentration step, respectively, so that a number of studies have reported an efficient selective preconcentration process, i.e. conducting the separation and preconcentration simultaneously. In this work, a power-free spontaneous selective preconcentration method was suggested based on leveraging convective flow over diffusiophoresis near the water-absorbing nanoporous ion exchange medium, which was verified both by simulation and experiment. Especially, the velocity of the convective flow by an imbibition deviated from the original tendency of t-1/2 due to non-uniformly patterned nanoporous medium that has multiple cross-sectional areas. As a result, the direction of particle's motion was controlled at one's discretion, which led to the spontaneous selective preconcentration of particles having different diffusiophoretic constant. Also, design rule for maximizing the efficiency was recommended. Thus, this selective preconcentration method would play as a key mechanism for power-free lab on a chip applications.

SUBMITTER: Lee D 

PROVIDER: S-EPMC6382859 | biostudies-other | 2019 Feb

REPOSITORIES: biostudies-other