Dataset Information
Efficient Tandem Addition/Cyclization for Access to 2,4-Diarylquinazolines via Catalytic Carbopalladation of Nitriles.
Ontology highlight
ABSTRACT:
SUBMITTER: Gong J
PROVIDER: S-EPMC6384746 | biostudies-other | 2019 Jan
REPOSITORIES: biostudies-other
Publications
Efficient Tandem Addition/Cyclization for Access to 2,4-Diarylquinazolines via Catalytic Carbopalladation of Nitriles.
Molecules (Basel, Switzerland) 20190128 3
The first example of the palladium-catalyzed tandem addition/cyclization of 2-(benzylidenamino)benzonitriles with arylboronic acids has been developed. This transformation features good functional group tolerance and provides an alternative synthetic pathway to access 2,4-diarylquinazolines in moderate to good yields. A plausible mechanism for the formation of 2,4-diarylquinazolines involving sequential nucleophilic addition followed by an intramolecular cyclization is proposed. ...[more]