Ontology highlight
ABSTRACT:
SUBMITTER: Guida M
PROVIDER: S-EPMC6386878 | biostudies-other | 2019 Feb
REPOSITORIES: biostudies-other
Guida Marianna M Zanon Alessandra A Montibeller Luigi L Lavdas Alexandros A AA Ladurner Judith J Pischedda Francesca F Rakovic Aleksandar A Domingues Francisco S FS Piccoli Giovanni G Klein Christine C Pramstaller Peter P PP Hicks Andrew A AA Pichler Irene I
International journal of molecular sciences 20190211 3
Mutations in the <i>PRKN</i> gene (encoding parkin) have been linked to the most frequent known cause of recessive Parkinson's disease (PD), and parkin dysfunction represents a risk factor for sporadic PD. Parkin is widely neuroprotective through different cellular pathways, as it protects dopaminergic neurons from apoptosis in a series of cellular and animal models of PD. The mitochondrial protein apoptosis-inducing factor (AIF) is an important cell death effector, which, upon cellular stress i ...[more]