Replacing P-values with frequentist posterior probabilities of replication-When possible parameter values must have uniform marginal prior probabilities.

ABSTRACT: The prior probabilities of true outcomes for scientific replication have to be uniform by definition. This is because for replication, a study's observations are regarded as samples taken from the set of possible outcomes of an ideally large continuation of that study. (The sampling is not done directly from some source population.) Therefore, each possible outcome is based on the same ideally large number of observations so that all possible outcomes for that study have the same prior probability. The calculation methods were demonstrated on a spreadsheet with simulated data on the distribution of people with an imaginary genetic marker. Binomial distributions are used to illustrate the concepts to avoid the effects of potentially misleading assumptions. Uniform prior probabilities allow a frequentist posterior probability distribution of a study result's replication to be calculated conditional solely on the study's observations. However, they can be combined with prior data or Bayesian prior distributions. If the probability distributions are symmetrical then the frequentist posterior probability of a true result that is equal to or more extreme than a null hypothesis will be the same as the one-sided P-value. This is an idealistic probability of replication within a specified range based on an assumption of perfect study method reproducibility. It can be used to estimate a realistic probability of replication by taking into account the probability of non-reproducible methods or subjects. A probability of replication will be lower if the subsequent outcome is a narrower range corresponding to a specified statistical significance, this being a more severe test. The frequentist posterior probability of replication may be easier than the P-value for non-statisticians to understand and to interpret.

SUBMITTER: Llewelyn H 

PROVIDER: S-EPMC6392266 | biostudies-other | 2019

REPOSITORIES: biostudies-other