Ontology highlight
ABSTRACT:
SUBMITTER: Yea K
PROVIDER: S-EPMC6401169 | biostudies-other | 2019 Mar
REPOSITORIES: biostudies-other
Yea Kyungmoo K Jones Teresa M TM Jung Dokyung D Shin Sanghee S Arlian Britni M BM Han Kyung Ho KH Zha Zhao Z Kim Minseok S MS Oh Yong-Seok YS Zhang Hongkai H Lerner Richard A RA
Scientific reports 20190305 1
Previously, we reported an agonist antibody to a cytokine receptor, Thrombopoietin receptor (TPOR) that effectively induces cytotoxic killer cells from precursor tumor cells isolated from newly diagnosed AML patients. Here, we show that the TPOR agonist antibody can induce even relapsed AML cells into killer cells more potently than newly diagnosed AML cells. After stimulation by the agonist antibody, these relapsed leukemic cells enter into a differentiation process of killer cells. The antibod ...[more]