Ontology highlight
ABSTRACT:
SUBMITTER: Neumeyer V
PROVIDER: S-EPMC6468876 | biostudies-other | 2019 Mar
REPOSITORIES: biostudies-other
Neumeyer Victoria V Vieth Michael M Gerhard Markus M Mejías-Luque Raquel R
Cancers 20190316 3
The E3 ubiquitin ligase ring finger protein 43 (RNF43) is frequently mutated in gastric tumors and loss of RNF43 expression was suggested to be one of the key events during the transition from adenoma to gastric carcinoma. Functional studies on RNF43 have shown that it acts as a tumor suppressor by negatively regulating Wnt signaling. Interestingly, we observed that RNF43<sup>H292R/H295R</sup> mice bearing two point mutations in the ring domain displayed thickening of the mucosa at early age but ...[more]