Dataset Information
Catalytic Asymmetric Fluorination of Alkyl 1-indanone-2-carboxylates Ruled by Pybox-Eu(III) Combination.
Ontology highlight
ABSTRACT:
SUBMITTER: Granados A
PROVIDER: S-EPMC6471818 | biostudies-other | 2019 Mar
REPOSITORIES: biostudies-other
Publications
Catalytic Asymmetric Fluorination of Alkyl 1-indanone-2-carboxylates Ruled by Pybox-Eu(III) Combination.
Molecules (Basel, Switzerland) 20190322 6
A highly enantioselective catalytic method for the synthesis of quaternary α-fluoro derivatives of 3-oxo esters is described. The reaction uses europium (III) triflate and commercially available chiral pybox-type C2-symmetric ligand. Excellent results in terms of yields and enantioselectivities were assured using the electrophilic NFSI reagent under mild reaction conditions. ...[more]