Ontology highlight
ABSTRACT:
SUBMITTER: Liang Y
PROVIDER: S-EPMC4004247 | biostudies-other | 2014 Apr
REPOSITORIES: biostudies-other
Journal of the American Chemical Society 20140331 14
The development of new approaches to the construction of fluorine-containing target molecules is important for a variety of scientific disciplines, including medicinal chemistry. In this Article, we describe a method for the catalytic enantioselective synthesis of tertiary alkyl fluorides through Negishi reactions of racemic α-halo-α-fluoroketones, which represents the first catalytic asymmetric cross-coupling that employs geminal dihalides as electrophiles. Thus, selective reaction of a C-Br (o ...[more]