Ontology highlight
ABSTRACT:
SUBMITTER: Pir GJ
PROVIDER: S-EPMC6476873 | biostudies-other | 2019 May
REPOSITORIES: biostudies-other
Molecular neurobiology 20180908 5
Tau aggregation is a hallmark of a group of neurodegenerative diseases termed Tauopathies. Reduction of aggregation-prone Tau has emerged as a promising therapeutic approach. Here, we show that an anti-aggregant Tau fragment (F3<sup>ΔKPP</sup>, residues 258-360) harboring the ΔK280 mutation and two proline substitutions (I<sup>277</sup>P & I<sup>308</sup>P) in the repeat domain can inhibit aggregation of Tau constructs in vitro, in cultured cells and in vivo in a Caenorhabditis elegans model of ...[more]