Ontology highlight
ABSTRACT:
SUBMITTER: Ahmad ST
PROVIDER: S-EPMC6494820 | biostudies-other | 2019 May
REPOSITORIES: biostudies-other
Ahmad Shiekh Tanveer ST Rogers Alexandra D AD Chen Myra J MJ Dixit Rajiv R Adnani Lata L Frankiw Luke S LS Lawn Samuel O SO Blough Michael D MD Alshehri Mana M Wu Wei W Marra Marco A MA Robbins Stephen M SM Cairncross J Gregory JG Schuurmans Carol C Chan Jennifer A JA
Nature communications 20190501 1
Capicua (Cic) is a transcriptional repressor mutated in the brain cancer oligodendroglioma. Despite its cancer link, little is known of Cic's function in the brain. We show that nuclear Cic expression is strongest in astrocytes and neurons but weaker in stem cells and oligodendroglial lineage cells. Using a new conditional Cic knockout mouse, we demonstrate that forebrain-specific Cic deletion increases proliferation and self-renewal of neural stem cells. Furthermore, Cic loss biases neural stem ...[more]