Ontology highlight
ABSTRACT:
SUBMITTER: Li Y
PROVIDER: S-EPMC6520809 | biostudies-other | 2019 Apr
REPOSITORIES: biostudies-other
Li Yao Y Xia Yuchen Y Cheng Xiaoming X Kleiner David E DE Hewitt Stephen M SM Sproch Julia J Li Tong T Zhuang Hui H Liang T Jake TJ
Viruses 20190425 4
Ground glass hepatocytes (GGHs), a histological hallmark of chronic hepatitis B virus (HBV) infection, contain excessive hepatitis surface antigen (HBsAg) in the endoplasmic reticulum (ER), which is linked to unfolded protein response (UPR). The mechanism by which HBV activates UPR has not been fully defined. To investigate this, HepG2-NTCP cells and primary human hepatocytes (PHHs) were either infected with HBV or transduced with adenoviral vectors expressing replication-competent HBV genome or ...[more]