Ontology highlight
ABSTRACT:
SUBMITTER: Chen Y
PROVIDER: S-EPMC6557837 | biostudies-other | 2019 Jun
REPOSITORIES: biostudies-other
Chen Yi Y Pais-Roldan Patricia P Chen Xuming X Frosz Michael H MH Yu Xin X Yu Xin X
Nature communications 20190610 1
Optical fiber-mediated optogenetic activation and neuronal Ca<sup>2+</sup> recording in combination with fMRI provide a multi-modal fMRI platform. Here, we developed an MRI-guided robotic arm (MgRA) as a flexible positioning system with high precision to real-time assist optical fiber brain intervention for multi-modal animal fMRI. Besides the ex vivo precision evaluation, we present the highly reliable brain activity patterns in the projected basal forebrain regions upon MgRA-driven optogenetic ...[more]