Ontology highlight
ABSTRACT:
SUBMITTER: Walker AK
PROVIDER: S-EPMC6588678 | biostudies-other | 2019 Jul
REPOSITORIES: biostudies-other
Walker Alexandra K AK Karaszi Katalin K Valentine Helen H Strauss Victoria Y VY Choudhury Ananya A McGill Shaun S Wen Kaisheng K Brown Michael D MD Ramani Vijay V Bhattarai Selina S Teo Mark T W MTW Yang Lingjian L Myers Kevin A KA Deshmukh Nayneeta N Denley Helen H Browning Lisa L Love Sharon B SB Iyer Gopa G Clarke Noel W NW Hall Emma E Huddart Robert R James Nicholas D ND Hoskin Peter J PJ West Catharine M L CML Kiltie Anne E AE
International journal of radiation oncology, biology, physics 20190315 4
<h4>Purpose</h4>Organ-confined muscle-invasive bladder cancer is treated with cystectomy or bladder preservation techniques, including radiation therapy. There are currently no biomarkers to inform management decisions and aid patient choice. Previously we showed high levels of MRE11 protein, assessed by immunohistochemistry (IHC), predicted outcome after radiation therapy, but not cystectomy. Therefore, we sought to develop the MRE11 IHC assay for clinical use and define its relationship to cli ...[more]