Ontology highlight
ABSTRACT:
SUBMITTER: Biggs R
PROVIDER: S-EPMC6589789 | biostudies-other | 2019 Mar
REPOSITORIES: biostudies-other
Molecular biology of the cell 20190109 7
During cell division, chromatin is compacted into mitotic chromosomes to aid faithful segregation of the genome between two daughter cells. Posttranslational modifications (PTMs) of histones alter compaction of interphase chromatin, but it remains poorly understood how these modifications affect mitotic chromosome stiffness and structure. Using micropipette-based force measurements and epigenetic drugs, we probed the influence of canonical histone PTMs that dictate interphase euchromatin (acetyl ...[more]