Ontology highlight
ABSTRACT:
SUBMITTER: Chen L
PROVIDER: S-EPMC6778080 | biostudies-other | 2019 Oct
REPOSITORIES: biostudies-other
Nature communications 20191004 1
Neonatal inflammatory diseases are associated with severe morbidity, but the inflammatory factors underlying them and their potential effector mechanisms are poorly defined. Here we show that necrotizing enterocolitis in neonate mice is accompanied by elevation of IL-23 and IL-22 and decreased production of pancreatic enzymes. These phenotypes are mirrored in neonate mice overexpressing IL-23 in CX3CR1<sup>+</sup> myeloid cells or in keratinocytes. The mice fail to grow and die prematurely, disp ...[more]