Ontology highlight
ABSTRACT:
SUBMITTER: Pajaro M
PROVIDER: S-EPMC6783536 | biostudies-other | 2019 Oct
REPOSITORIES: biostudies-other
Nature communications 20191008 1
Cell fate determination, the process through which cells commit to differentiated states is commonly mediated by gene regulatory motifs with mutually exclusive expression states. The classical deterministic picture for cell fate determination includes bistability and hysteresis, which enables the persistence of the acquired cellular state after withdrawal of the stimulus, ensuring a robust cellular response. However, stochasticity inherent to gene expression dynamics is not compatible with hyste ...[more]