Ontology highlight
ABSTRACT:
SUBMITTER: Worsdorfer P
PROVIDER: S-EPMC6821804 | biostudies-other | 2019 Oct
REPOSITORIES: biostudies-other
Wörsdörfer Philipp P Dalda Nahide N Kern Anna A Krüger Sarah S Wagner Nicole N Kwok Chee Keong CK Henke Erik E Ergün Süleyman S
Scientific reports 20191030 1
Organoids derived from human pluripotent stem cells are interesting models to study mechanisms of morphogenesis and promising platforms for disease modeling and drug screening. However, they mostly remain incomplete as they lack stroma, tissue resident immune cells and in particular vasculature, which create important niches during development and disease. We propose, that the directed incorporation of mesodermal progenitor cells (MPCs) into organoids will overcome the aforementioned limitations ...[more]