Ontology highlight
ABSTRACT:
SUBMITTER: Santra M
PROVIDER: S-EPMC6825304 | biostudies-other | 2019 Oct
REPOSITORIES: biostudies-other
Santra Mantu M Dill Ken A KA de Graff Adam M R AMR
Proceedings of the National Academy of Sciences of the United States of America 20191016 44
What molecular processes drive cell aging and death? Here, we model how proteostasis-i.e., the folding, chaperoning, and maintenance of protein function-collapses with age from slowed translation and cumulative oxidative damage. Irreparably damaged proteins accumulate with age, increasingly distracting the chaperones from folding the healthy proteins the cell needs. The tipping point to death occurs when replenishing good proteins no longer keeps up with depletion from misfolding, aggregation, a ...[more]