IL-27 maintains cytotoxic Ly6C+ gamma delta T cells that arise from immature precursors

ABSTRACT: In mice, -T lymphocytes that express the co-stimulatory molecule, CD27, are committed to the IFN- producing lineage during thymic development. In the periphery, these cells play a critical role in host defence and anti-tumor immunity. Unlike -T cells that rely on MHC-presented peptides to drive their terminal differentiation, it is unclear whether MHC-unrestricted -T cells undergo further functional maturation after exiting the thymus. Here, we provide evidence of phenotypic and functional diversity within peripheral IFN-producing  T cells. We found that CD27+ Ly6C- cells convert into CD27+Ly6C+ cells, and these CD27+Ly6C+ cells control cancer progression in mice, while the CD27+Ly6C- cells cannot. The gene signatures of these two subsets were highly analogous to human immature a

SUBMITTER: Dr. Robert Wiesheu 

PROVIDER: S-SCDT-10_1038-S44318-024-00133-1 | biostudies-other |

REPOSITORIES: biostudies-other