The 24-Hour Molecular Landscape After Exercise in Humans Reveals MYC is Sufficient for Muscle Growth

ABSTRACT: A detailed understanding of molecular responses to a hypertrophic stimulus in skeletal muscle leads to therapeutic advances aimed at promoting muscle mass. To decode the molecular factors regulating skeletal muscle mass, we utilized a 24-hour time course of human muscle biopsies after a bout of resistance exercise. Our findings indicate: 1) the DNA methylome response at 30 minutes corresponds to upregulated genes at 3 hours, 2) a burst of translation- and transcription-initiation factor-coding transcripts occurs between 3 and 8 hours, 3) changes to global protein-coding gene expression peaks at 8 hours, 4) ribosome-related genes dominate the mRNA landscape between 8 and 24 hours, 5) methylation-regulated MYC is a highly influential transcription factor throughout recovery. To test whether

SUBMITTER: Dr. Sebastian Edman 

PROVIDER: S-SCDT-10_1038-S44319-024-00299-Z | biostudies-other |

REPOSITORIES: biostudies-other