Dengue virus preferentially uses human and mosquito non-optimal codons

ABSTRACT: Codon optimality refers to the effect that codon composition has on messenger RNA (mRNA) stability and translation level and implies that synonymous codons are not silent from a regulatory point-of-view. Here, we investigated the adaptation of virus genomes to the host optimality code using mosquito-borne dengue virus (DENV) as a model. We demonstrated that codon optimality exists in mosquito cells and showed that DENV preferentially uses non-optimal (destabilizing) codons and avoids codons that are defined as optimal (stabilizing) in either human or mosquito cells. Human genes enriched in the codons preferentially and frequently used by DENV are up-regulated during infection, and so is the tRNA decoding the non-optimal and DENV preferentially used codon for arginine. We found that adaptat

SUBMITTER: Luciana, Andrea Castellano 

PROVIDER: S-SCDT-10_1038-S44320-024-00052-7 | biostudies-other |

REPOSITORIES: biostudies-other