TRIM71 reactivation enhances the mitotic and hair cell-forming potential of cochlear-supporting cells

ABSTRACT: Cochlear hair cell loss is a leading cause of deafness in humans. Neighboring supporting cells have some capacity to regenerate hair cells. However, their regenerative potential sharply declines as supporting cells undergo maturation (postnatal day 5 in mice). We recently reported that reactivation of the RNA-binding protein LIN28B restores the hair cell-regenerative potential of P5 cochlear supporting cells. Here, we identify the LIN28B target Trim71 as a novel and equally potent enhancer of supporting cell plasticity. TRIM71 is a critical regulator of stem cell behavior and cell reprogramming, however, its role in cell regeneration is poorly understood. Employing an organoid-based assay, we show that TRIM71 re-expression increases the mitotic and hair cell-forming potential of P5 cochlea

SUBMITTER: Dr. Xiao-Jun Li 

PROVIDER: S-SCDT-10_15252-EMBR_202256562 | biostudies-other |

REPOSITORIES: biostudies-other