Potentiation of neuronal activity by tonic GluD1 current in brain slices

ABSTRACT: Ion channel function of native delta glutamate receptors (GluDRs) is incompletely understood. Previously, we and others have shown that activation of Gαq protein-coupled receptors (GqPCR) produces a slow inward current carried by GluD1R. GluD1R also carry a tonic cation current of unknown cause. Here, using voltage-clamp electrophysiological recordings from adult mouse brain slices containing the dorsal raphe nucleus, we find no role of on-going G protein-coupled receptor activity in generating or sustaining tonic GluD1R currents. Neither augmentation nor disruption of G protein activity affects tonic GluD1R currents, suggesting that on-going G protein-coupled receptor activity does not give rise to tonic GluD1R currents. Further, the tonic GluD1R current is unaffected by the addition of e

SUBMITTER: Mr. Daniel, S Copeland 

PROVIDER: S-SCDT-10_15252-EMBR_202356801 | biostudies-other |

REPOSITORIES: biostudies-other