Ontology highlight
ABSTRACT:
SUBMITTER: Saliba RS
PROVIDER: S-EPMC3395084 | biostudies-other | 2012 Jun
REPOSITORIES: biostudies-other
Saliba Richard S RS Kretschmannova Karla K Moss Stephen J SJ
The EMBO journal 20120424 13
The expression of GABA(A) receptors and the efficacy of GABAergic neurotransmission are subject to adaptive compensatory regulation as a result of changes in neuronal activity. Here, we show that activation of L-type voltage-gated Ca(2+) channels (VGCCs) leads to Ca(2+)/calmodulin-dependent protein kinase II (CaMKII) phosphorylation of S383 within the β3 subunit of the GABA(A) receptor. Consequently, this results in rapid insertion of GABA(A) receptors at the cell surface and enhanced tonic curr ...[more]