Excessive apoptosis of Rip1-deficient T cells leads to premature aging

ABSTRACT: In mammals, the most remarkable T cell variations with aging are the shrinking of the naïve T cell pool and the enlargement of the memory T cell pool, which are partially caused by thymic involution. However, the mechanism underlying the relationship between T-cell changes and aging remains unclear. In this study, we find that T-cell specific Rip1 KO mice show similar age-related T cell changes and exhibit signs of accelerated aging-like phenotypes, including inflammation, multiple age-related diseases and a shorter lifespan. Mechanistically, Rip1-deficient T cells undergo excessive apoptosis, and promote chronic inflammation. Consistent with this, blocking apoptosis by co-deletion of Fadd in Rip1-deficient T cells significantly rescues lymphopenia, the imbalance between naïve and memory T

SUBMITTER: Lingxia Wang 

PROVIDER: S-SCDT-10_15252-EMBR_202357925 | biostudies-other |

REPOSITORIES: biostudies-other