A spatial multi-omics atlas of the human lung reveals a novel immune cell survival niche

ABSTRACT: Single-cell transcriptomics has allowed unprecedented resolution of cell types/states in the human lung, but their spatial context is less well defined. To (re)define tissue architecture of lung and airways, we profiled five proximal-to-distal locations of healthy human lungs in depth using multi-omic single cell/nuclei and spatial transcriptomics (queryable at lungcellatlas.org). Using computational data integration and analysis, we extend beyond the suspension cell paradigm and discover macro and micro-anatomical tissue compartments including previously unannotated cell types in the epithelial, vascular, stromal and nerve bundle micro-environments. We identify and implicate peribronchial fibroblasts in lung disease. Importantly, we discover and validate a survival niche for IgA plasma ce

SUBMITTER: Elo Madissoon 

PROVIDER: S-SUBS17 | biostudies-other |

SECONDARY ACCESSION(S): SAMEA14081226

REPOSITORIES: biostudies-other