Dataset Information

Study of Adaptation to Hypoxia in Ethiopian Highlanders

ABSTRACT:

Although it has long been proposed that genetic factors contribute to adaptation to high altitude, such factors remain largely unverified. Recent advances in high-throughput sequencing have made it feasible to analyze genome-wide patterns of genetic variation in human populations. Since traditionally such studies surveyed only a small fraction of the genome (either exons or a subset of SNPs) or a group of candidate genes, interpretation of the results was limited.

We focused our study on Ethiopian highlander populations, which have been found to be well adapted to high altitudes (~3500m). We sequenced and analyze the genomes of 13 high altitude native Ethiopians: 6 individuals of Oromo heritage living on Bale Plateau (labeled "Oromos"), and 7 individuals residing on the Chennek field in the Simien Mountains (labeled "Amhara").

Our study revealed evolutionarily conserved genes that modulate hypoxia tolerance.

PROVIDER: phs000647 | dbGaP |

SECONDARY ACCESSION(S): PRJNA214262PRJNA214263

REPOSITORIES: dbGaP

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Dataset's files

Source:

			Action	DRS
	GapExchange_phs000647.v1.p1.xml	Xml
	dbGaPEx2.1.5.xsd	Other
	Study_Report.phs000647.HypoxiaTolerance_EthiopianHighlanders.v1.p1.MULTI.pdf	Pdf
	manifest_phs000647.HypoxiaTolerance_EthiopianHighlanders.v1.p1.c1.GRU.pdf	Pdf
	datadict_v2.xsl	Other

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Dataset Information

Study of Adaptation to Hypoxia in Ethiopian Highlanders

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