Dataset Information

Plasma proteomics of Ghanian children from high malaria transmission (HMT) and low malaria transmission (LMT) zones

ABSTRACT: We performed a longitudinal study of the plasma proteome of children infected with malaria and residing in low or high malaria transmission areas in Ghana. A mass spectrometry-based approach was used to identify putative protein-based biomarkers and predictors of resistance to malaria. Our findings confirm earlier reports and identify putative signature proteins implicated in immune tolerance to malaria.

INSTRUMENT(S): timsTOF HT

ORGANISM(S): Plasmodium Falciparum Homo Sapiens (human)

TISSUE(S): Blood Plasma, Bodily Fluid

DISEASE(S): Malaria

SUBMITTER: Mehdi Bouhaddou

LAB HEAD: Mehdi Bouhaddou

PROVIDER: PXD060218 | Pride | 2025-02-11

REPOSITORIES: pride

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			Action	DRS
	DIA-NN_Search_Results.xlsx	Xlsx
	keys.txt	Txt
	rawfiles.zip	Other

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Publications

Malaria exposure remodels the plasma proteome of Ghanaian children.

Mohammed Aisha M AM Olwal Charles Ochieng' CO Fossati Andrea A Nyakoe Nancy K NK Fabius Jacqueline M JM Gordon Martin M Polacco Benjamin J BJ Swaney Danielle L DL Awandare Gordon A GA Krogan Nevan J NJ Bouhaddou Mehdi M Bediako Yaw Y

BMC infectious diseases 20250203 1

<h4>Background</h4>Malaria, caused by Plasmodium falciparum, remains a major public health burden causing ~ 200 million deaths annually, especially among children. Although the lack of an effective vaccine has hindered malaria elimination, studies have reported on individuals acquiring natural immunity to malaria in the context of high malaria exposure. However, the immune correlates of protection in these people who acquire natural immunity against malaria are poorly understood.<h4>Methods</h4> ...[more]

PMID: 39901099

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