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Linked Read Sequencing of Gastric Cancer Metastases

ABSTRACT:

In this study, linked read sequencing was performed on two ovarian metastases and matched normal tissue, from a patient with primary diffuse gastric cancer. Linked read sequencing is a DNA preparation technology whereby high molecular weight molecules of DNA are uniquely barcoded prior to fragmentation and sequencing, thus retaining information about genomic contiguity. This study performed an extended analysis of linked read sequencing data to resolve the complex structures of structural variants in the cancer genomes. Complex structural rearrangements were identified in the genomic region surrounding the known oncogene FGFR2, and the association between FGFR2 and gastric cancer metastasis was demonstrated in an organoid model.

PROVIDER: phs001362 | dbGaP |

SECONDARY ACCESSION(S): PRJNA384278PRJNA384277

REPOSITORIES: dbGaP

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Dataset's files

Source:

			Action	DRS
	GapExchange_phs001362.v1.p1.xml	Xml
	dbGaPEx2.1.5.xsd	Other
	Study_Report.phs001362.GastricCancer.v1.p1.MULTI.pdf	Pdf
	manifest_phs001362.GastricCancer.v1.p1.c2.HMB-PUB-NPU-MDS.pdf	Pdf
	datadict_v2.xsl	Other

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