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Time Lapse to Cancer-Defining the Transition from Polyp to Cancer

ABSTRACT:

In the US, CRC incidence has declined with uptake in colonoscopy for early detection and removal of polyps, the precursor lesion, can stop a cancer from developing but in spite of this, CRC remains the second leading cause of cancer death in the United States. One third of people who undergo screening colonoscopy will have adenomatous polyps, but less than 5% of the time are these polyps presumed to go on to develop into cancer. Why does one polyp develop into cancer while another one that looks very similar does not. In this proposal we will identify what molecular genetic changes in the genome, in the mRNA expression and genetic methylation patterns will distinguish a polyp that has already transformed into cancer from one that has not.

PROVIDER: phs001384 | dbGaP |

SECONDARY ACCESSION(S): PRJNA391042PRJNA391043

REPOSITORIES: dbGaP

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
	GapExchange_phs001384.v1.p1.xml	Xml
	dbGaPEx2.1.5.xsd	Other
	Study_Report.phs001384.PolypToCancer.v1.p1.MULTI.pdf	Pdf
	manifest_phs001384.PolypToCancer.v1.p1.c1.HMB.pdf	Pdf
	datadict_v2.xsl	Other

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